T-cell immunotherapy for B-cell malignancies and viral infections
Dr Wei Jiang, Westmead Cellular Therapies Group (Sydney)
Funding period: 2019 – 2022
This PhD is kindly supported by the Bill Long Charitable Trust, managed by Equity Trustees.
Dr Wei Jiang will be conducting two trials to establish the clinical safety and efficacy of T-cell immunotherapies for infection and malignancy; and the detailed functional, phenotypic and molecular changes in patients’ blood post T-cell therapy.
The research team will conduct a clinical trial of autologous CD19 chimeric antigen receptor (CAR) T-cells generated using the PiggyBac system for relapsed or refractory B-cell malignancies such as acute lymphoblastic leukaemia (ALL) and lymphoma. This is revolutionary research, as CAR T-cells can be generated with this technology for a fraction of the cost of those produced using viral vector, making CAR T-cells more affordable to patients. This research aims to establish the safety and efficacy of PiggyBac CAR19 T-cells in a cohort of 20 patients.
This research will also examine into pathogen-specific T-cells for therapy resistant viral infections after an allogenic haemopoietic stem cell transplant (HSCT), which can lead to significant morbidity and mortality. Dr Jiang and team will run a Phase lll study assessing the safety and efficacy of administering banked 3rd party donor derived infection-specific T-cells to patients with resistant viral infections such as cytomegalovirus (CMV), Epstein-Barr virus (EBV or adenovirus).
PhD scholarships are co-funded by the Leukaemia Foundation and the Haematology Society of Australia and New Zealand (HSANZ).