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Solitary plasmacytoma

What is plasmacytoma?

Plasmacytoma refers to a tumour consisting of abnormal plasma cells that grows within the soft tissue or bony skeleton. It can be present as a discreet solitary mass of abnormal plasma cells, in which case it is termed a “solitary” plasmacytoma or it can be present as part of myeloma. The prognosis and treatment of solitary plasmacytomas is very different to myeloma.

Plasma cells are a type of white blood cell that develops from mature B-lymphocytes in the bone marrow. They play an important role in protecting the body against infection and disease by producing proteins called immunoglobulins (Ig), also known as antibodies.

There are two main types of solitary plasmacytomas:

  • Solitary bone plasmacytoma (SBP) – where there is localised build-up of abnormal plasma cells in the bone. Most commonly, these tumours develop in the spinal column but they may also develop in the pelvis, ribs, arms, face, skull, femur (thigh), and sternum (breast bone).Some people with SBP may go on to develop multiple myeloma – around 50-70% over 10 years – so you’ll be regularly monitored with blood tests and x-rays and/or MRI scans.
  • Solitary extramedullary plasmacytoma (SEP) – where the clump of abnormal plasma cells occurs outside the bone in soft tissue. These plasmacytomas most commonly occur in the head and neck region, particularly in the upper airways (nose, throat and sinuses), but may also be found in the gastrointestinal tract, lymph nodes, bladder, lung or other organs. There is less than a 10% chance of this disease progressing to myeloma.
  • Solitary plasmacytomas do not have the typical features of myeloma, which include low red blood cell counts, elevated calcium levels in the blood, or reduced kidney function. And although 75% of people with SBP and 25% of people with SEP have an M-protein (abnormal proteins produced by the cancerous plasma cells), they are usually small and disappear following treatment.


A solitary plasmacytoma most commonly occurs in middle-aged or elderly people and is very rare under the age of 30. The median age at diagnosis is about a decade younger than that of people with myeloma, 55 to 65 years, compared to a median age of 71 years for patients diagnosed with multiple myeloma.

Solitary bone plasmacytomas are uncommon and make up approximately 5% of all of the plasma cell disorders. Solitary extramedullary plasmacytomas are even less common. Solitary plasmacytomas occur more commonly in men than women.


It is not known what causes plasmacytomas.


Solitary bone plasmacytomas may cause bone pain or fractures. Symptoms depend on where the tumour is located.


A person is diagnosed with a solitary plasmacytoma when: a biopsy reveals a single tumour inside the bone or tissue comprising abnormal plasma cells; x-rays, positron electron tomography (PET scan) or magnetic resonance imaging (MRI) scans show no other lesions in the bone or in the soft tissues; bone marrow biopsy shows no evidence of myeloma; and blood tests show no signs of anaemia, high calcium or reduced kidney function due to the M-protein.


The treatment used most commonly for both types of plasmacytoma is radiotherapy. This is possible because by definition, “solitary plasmacytomas” are localised. Radiotherapy involves focusing radiation (similar to x-rays) on the plasmacytoma to kill the abnormal cells. The treatment is generally given over several days to reduce side-effects.

Although chemotherapy is generally not used in addition to radiotherapy, there are times when the types of medications used to treat myeloma are considered.

Surgery is rarely necessary but may be required in situations where plasmacytoma involvement of the bone causes skeletal instability and high risk of fracture. In these cases, radiation therapy may be delayed until after surgery.

Radiotherapy generally provides excellent local and often durable control of the plasmacytoma. However, there is a risk that plasmacytomas may recur or progress to myeloma (particularly with SBP). All people with plasmacytomas require life-long follow-up. This generally involves physical examination, blood and urine tests, and x-rays, MRI or PET scans at regular intervals for at least the first five years after treatment has been completed.

Last updated on December 15, 2023

Developed by the Leukaemia Foundation in consultation with people living with a blood cancer, Leukaemia Foundation support staff, haematology nursing staff and/or Australian clinical haematologists. This content is provided for information purposes only and we urge you to always seek advice from a registered health care professional for diagnosis, treatment and answers to your medical questions, including the suitability of a particular therapy, service, product or treatment in your circumstances. The Leukaemia Foundation shall not bear any liability for any person relying on the materials contained on this website.

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