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Evaluating the evidence base, current practice and clinical outcomes of immunoglobulin treatment

Khai Li Chai
Dr Khai Li Chai, Monash University (Melbourne)
Funding period: 2020-2023

This research project is kindly supported through the Estate of Davina Sickerdick.

Dr Khai Li Chai is specialist clinical and laboratory haematologist. She graduated with honours from the University of Melbourne, and completed her specialist training at St Vincent’s Hospital Melbourne and Peter MacCallum Cancer Centre. She is completing a thrombosis fellowship at Northern Health with imminent plans to commence a PhD at Monash University. Her research interests lie in the fields of transfusion medicine, haemostasis and thrombosis.

Patients with chronic lymphocytic leukaemia, non-Hodgkin lymphoma, multiple myeloma and patients who have undergone an allogeneic stem cell transplant frequently develop acquired hypogammaglobulinaemia due to underlying disease or as a consequence of treatment. Acquired hypogammaglobulinaemia is a condition where the body does not produce enough antibodies and can be associated with serious and/or recurrent infections. It is a significant cause of mortality and morbidity in these patients. Immunoglobulin replacement therapy is frequently administered in these patients but there are substantial variations in recommendations and practice internationally with no clearly defined standard of care.

Dr Chai’s project will evaluate the evidence base, current practice and clinical outcomes of immunoglobulin treatment and investigate how detailed patient immune profiles can be used to guide and monitor optimal dosing and duration of immunoglobulin therapy.

PhD scholarships are co-funded by the Leukaemia Foundation and the Haematology Society of Australia and New Zealand (HSANZ).