PBAC considers plitidepsin for myeloma
The Pharmaceutical Benefits Advisory Committee (PBAC) considered four blood cancer treatments at its March meeting including a drug for myeloma – plitidepsin (Aplidin®).
The plitidepsin submission, submitted by Specialised Therapeutics, is for plitidepsin in combination with dexamethasone for people with relapsed or refractory myeloma who have had three prior treatment regimens*.
Summary clinical trial information indicates plitidepsin, which is administered in hospital as an IV therapy, was well tolerated and reduced the risk of disease progression and death.
The Leukaemia Foundation welcomes the availability of new treatment options and provided consumer comments in a submission to the PBAC in February 2020. These comments reflect the everyday experiences of people living with myeloma as requested through our disease-specific community groups on Facebook. A Victorian patient made the following comment:
“Very excited to hear of new drugs coming from nature – powerful bio-active agents have proven to wildly useful in medicine to date, and have only heard good things about the prospects of this drug for myeloma, which is known to be strongly relapsing to treatment. So while I’m not using it as yet, to have it in the arsenal of available drugs in the future is very encouraging.”
In its submission, the Leukaemia Foundation said: “the benefits of more effective and well tolerated treatments on the lives of individuals with myeloma cannot be underestimated. We assist myeloma patients over the course of their experience with this blood cancer and we know they would welcome the availability of a new treatment option”.
“The impact of this incurable cancer and the cytotoxic effects of treatment have an immeasurable impact on people’s lives and the lives of their families and carers.
“Giving clinicians more options in their ‘toolbox’ in the fight against myeloma, and removing barriers so patients can commence treatments tailored to their disease without any undue delays, is vitally important.”
The Leukaemia Foundation also made comments to the July 2019 PBAC meeting for a previous submission for plitidepsin for myeloma.
* At least three treatments including both a proteasome inhibitor (PI) and an immunomodulator (IMiD), or in patients who have received two prior lines of therapy, if the patient is refractory and/or intolerant to both a PI and an IMiD.Posted on March 18th, 2020
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